Automated Evaluation Platform to Validate Performance of an Integrated Microfluidic Pump and Valve Experiment Control System for Tissue-Chips-In-Space and Chemical Mixing Experiments in Microgravity

Status: Completed

Start Date: 2019-10-01

End Date: 2025-04-30

Description:

Dynamic fluid experiments in space are challenging due to limitations of current syringe-based devices and astronaut time. The VIPER microfluidic control system overcomes those challenges by automating complex biological and chemical mixing experiments. This miniature pump-and-valve system with multiple small fluid reservoirs provides a general-purpose control platform for fluidic experiments in microgravity. It employs time-division fluidic multiplexing, which mimics circadian and diurnal rhythms. Sensors monitor temperature, humidity, and dissolved gas concentrations within fluidics, providing comprehensive information to scientists.

Problem Statement 
This technology is a novel, general-purpose, automated microfluidic experiment control platform optimized for use in volume-limited space vehicles. It is designed to meet the challenge of performing dynamic, small, fluidic volume experiments in space. This test is to demonstrate the robustness and basic functionality of the device and control system for experimental protocols.

Technology Maturation 
The VIPER platform has been extensively tested in ground-based laboratories but has not yet been tested in launch, orbital microgravity, or recovery. Demonstration of its robustness and reliability during and after a suborbital flight will help move the technology into the space-based research and commercial arena.

Benefits:

The VIPER system provides micro-volume chambers for up to eight experiments in a compact package. It supports complicated arrays of microbioreactor chambers and executes precise, preprogrammed, computer-controlled protocols. This would benefit future NASA missions and the commercial space industry.

Future Customers
• Tissue chips, stem cell differentiation, and sentinel cell maintenance
• Chemical/Pharmaceutical synthesis
• Tissue engineering (regenerative, repair)
• Combined component crystallization processes

Lead Organization: Vanderbilt University